These Guiding Principles for Cross-cultural Collaboration provide the foundation for a new way of working rooted in reconciliation, healing and collaboration to protect, restore and conserve species and natural environments. They will form the core of a forthcoming toolkit being developed by the Indigenous Knowledge Circle (IKC) of the National Boreal Caribou Knowledge Consortium (NBCKC). The current file version is April 2022. Should the reader have any comments or content amendments to propose, please contact the Indigenous Knowledge Circle as they continue development of their toolkit.